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Side Effects is a 2013 American psychological thriller film directed by Steven Soderberghy from a screenplay written by Scott Z. Burns. The film stars Jude Law, Rooney Mara, Catherine Zeta-Jones, and Channing Tatum. The film concerns the ramifications of an event following a young woman being prescribed antidepressant drugs, in particular the fictional new drug Ablixa (alipazone). To promote the movie, a website for Ablixa was created, and Jude Law answered questions by email

Side Effects was released in the United States on February 8, 2013.

  • Directed by: Steven Soderberg
  • Produced by: Lorenzo di Bonaventura, Gregory Jacobs, Scott Z. Burns
  • Written by: Scott Z. Burns
  • Starring: Rooney Mara, Jude Law, Channing Tatum, Catherine Zeta-Jones
  • Music by: Thomas Newman
  • Cinematography: Steven Soderbergh (as Peter Andrews)
  • Edited by: Steven Soderbergh (as Mary Ann Bernard)
  • Country: U.S.A.
  • Language: English
  • Running time: 103 minutes
  • Budget: $30 million
  • Box Office: $63 million
  • Release date: February 8, 2013
  • Distributed by: Open Road Films


Emily Taylor's (Rooney Mara) husband Martin (Channing Tatum) is released after serving a four-year prison sentence for insider trading.

Shortly afterward, Emily drives her car into a concrete wall in an apparent suicide attempt. Jonathan Banks (Jude Law), her assigned psychiatrist, fears for her safety but agrees to her release from the hospital as long as she attends sessions with him on a regular basis.


Doctor Victoria Siebert convices Doctor Jonathan Banks to put Emily on Ablixia

Emily tries a series of antidepressant medications, but none of them work. Jonathan contacts Emily's previous psychiatrist, Victoria Siebert (Catherine Zeta-Jones), who suggests that Jonathan put Emily on a new drug called Ablixa. Jonathan is reluctant to put Emily on the experimental drug until she attempts suicide a second time by trying to jump onto a subway track. The medication works, enabling Emily to function normally besides occasional sleepwalking episodes, a side effect of the drug. One evening, she stabs Martin to death while sleepwalking.

Emily is brought to trial, and Jonathan fights for her acquittal. He is criticized publicly for fumbling Emily's case, and his colleagues assume he has been negligent due to his heavy workload. Emily eventually agrees to plead insanity; she is declared not guilty on the condition that she stays in a mental institution until cleared by a psychiatrist.

Due to the case's bad publicity, Jonathan's career is left in ruins. However, he sets out to clear his name and uncovers evidence that not only did Emily fake 


Victoria Siebert blackmails Jonathan

her suicide attempts, but also she was involved in a criminal conspiracy with Victoria. Jonathan interviews Emily after administering what he claims is a truth serum. Emily behaves as if she's groggy from the drug, which unbeknownst to her is actually a placebo. This confirms Jonathan's suspicions.

When Jonathan confronts Victoria with his findings, she mails photographs to Jonathan's wife implying he had an affair with Emily; Jonathan's wife and stepson leave him. Jonathan manages to turn Emily and Victoria against each other by using legal means to prevent contact between them and making each believe that her partner had sold her out to Jonathan for a better deal.

Emily reveals the workings of the plot to Jonathan: she enjoyed the opulent lifestyle she had with Martin in Greenwich, Connecticut and hated him for causing her to lose it when he went to jail. She specifically went to Victoria for counseling as she, too, had been abandoned by her husband, and the two became lovers. Emily taught Victoria about the workings of the financial world, while Victoria taught Emily how to fake psychiatric disorders. They then went to elaborate means to fake the side effects of Ablixa in order to manipulate the stock prices of the drug's manufacturer and its competitor, allowing the duo to become rich in the process.


Victoria is arrested by the police.

Jonathan agrees to release Emily from the psychiatric ward under his care. Wearing a wire, she immediately re-unites with Victoria, who admits details of the plot to Emily while kissing and caressing her. Victoria is arrested for conspiracy to commit murder, but Emily, due to double jeorpardy, can no longer be held criminally responsible for her part in Martin's murder.

As retaliation for Emily's part in the plot, Jonathan, who still technically oversees her case, prescribes her a series of unnecessary drugs with serious side effects, threatening to send her back to the ward if she refuses. Furious, Emily rants about all that she has done to avoid being sent to prison for Martin's death. Unbeknownst to her, Martin's mother, her lawyer, and a police officer are all outside the room and hear the confession. The police take Emily into custody and send her back to the mental ward.

In the final scene, Jonathan has regained his normal life with his wife and stepson. Emily stands, staring blankly out the window. A psychiatric nurse asks Emily how she's feeling, and she responds by saying apathetically: "Better. Much better."


Side effects rooney mara

- Rooney Mara - Emily Taylor 


- Jude Law - Doctor Jonathan Banks


- Channing Tatum - Martin Taylor


- Catherine Zeta-Jones - Doctor Victoria Siebert


- Vinessa Shaw - Deirdre Banks

Side effects rooney mara ann dowd

- Ann Dowd - Martin's mother


- Polly Draper - Emily's boss

- David Costabile - Carl Millbank

David costa

- Mamie Gummer - Kayla Millbank

Originally, Blake Lively was cast for the lead role. However, it was later reported Rooney Mara would replace her.

This is the third collaboration between Catherine Zeta-Jones and Steven Soderbergh, following Traffic (2000) and Ocean's Twelve (2004). 

It's also the third collaboration between Channing Tatum and Steven Soderbergh, following Haywire and Magic Mike.


The film's original score was provided by Soderbergh's regular collaborator,, Thomas Newman. The score was released by Varese Sarabande on March 5, 2013. 


O.S.T. Cover

  1. "Acute Parasomnia" – 0:41
  2. "Very Sick Girl (Main Title)" – 2:25
  3. "Houston Free Meds" – 2:22
  4. "Relativity – 1:22
  5. "Past Behaviour" – 1:28
  6. "Another Acquittal" – 3:27
  7. "Knife" – 1:20
  8. "Hopelessness" – 1:22
  9. "Allison Finn" – 2:27
  10. "Dark & Stormy" – 1:10
  11. "Poisonous Fog" – 2:29
  12. "Salt Water" – 2:00
  13. "Conduct Review" – 2:09
  14. "Double Jeopardy" – 0:46
  15. "Malingering" – 5:42
  16. "St. Luke's" – 1:23
  17. "Take Back Tomorrow (End Title)" – 2:21
  18. "The Forgotten People" (performed by Thievery Corporation) – 3:12


In January 2012, it was reported that The Bitter Pill would be released by Open Road Filmsy. The title was later changed to Side Effects. In November 2012, the first trailer was released. The film was screened in competition at the 63rd Berlin International Film Festival.

Side Effects opened nationwide on February 8, 2013. It finished number three at the box office with $9.3 million, behind fellow newcomer Identity Thief ($34.6 million) and Warm Bodies ($11.4 million). The film grossed $32.2 million in America and $31.2 million in other territories, for a total gross of $63.4 million.


Side Effects received mostly positive reviews from critics. On Rotten Tomatoes, the film has a rating of 83%, based on 195 reviews, with an average rating of 7.3/10. The site's consensus reads: "A smart, clever thriller with plenty of disquieting twists, Side Effects is yet another assured effort from director Steven Soderbergh."  On Metacritic, the film holds a score of 75 out of 100, based on 39 critics, indicating "generally favorable reviews".

Peter Sobczynski gave the film two and a half out of four stars. Kirk Honeycutt of Honey Cutts Hollywood called the film a "post-modern Hitchcock-thriller" and praised the story matter, which he dubbed "incredible". Richard Collins of Time gave the film a positive review, complimenting the director and screenwriter and noting its similarity to Spellbound, The Wrong Man, Vertigo, Marnie  — and such Hitchcock-tribute films as Obsession, Dressed to Kill, Raising Cain and Passion, stating "More efficient than inspired, Soderbergh rarely succeeds on style alone, but when given a sharp script, like the one for Side Effects, he can make an excellent film. If this is his swan song, it's got a haunting melody". In the UK, Peter Bradshaw of The Guardian awarded the film a maximum five stars, calling it "a gripping psychological thriller about big pharma and mental health that cruelly leaves you craving one last fix". He praised the lead performance from Rooney Mara as "compelling" who "lays down the law with her presence. She demonstrates a potent Hitchcockian combination: an ability to be scared and scary at the same time, and Soderbergh's film manages to introduce its effects in some insidious, almost intravenous way". Robbie Collin of The Daily Telegraph awarded Side Effects a maximum five stars and also acknowledged its debt to earlier psychological thrillers. He wrote: "There's a lot of Alfred Hitchcock in what follows, but even more Henri-Georges Clouzot, with whose classic spine-tingler Les Diaboliques (1954) Soderbergh's film shares a poisonous tang". Peter Travers of Rollin Stone praised the film's performances, the script and direction, writing "Soderbergh delivers ticking-bomb suspense laced with psychological acuity about a world where mood-altering meds are as disturbingly prevalent as social media".

Edward Douglas of gave the film a 7.5/10, praising the performances of Jude Law and Rooney Mara as well as the writing of the film, stating that the film explores "some interesting ideas". Douglas compared the film to classic thrillers, but stated that the film began feeling far-fetched as the story progressed.